P.102 Childhood Absence Epilepsy: Prevalence of treatment resistance and neuropsychiatric comorbidity.

Background: Seizures in childhood absence epilepsy (CAE) are usually easily controlled with anti-seizure medications (ASMs). Factors predictive of treatment resistance remain unclear. Our objectives were to assess prevalence neuropsychiatric problems and factors influencing refractoriness a cohort CAE at single centre. Methods: We retrospectively reviewed patients (ILAE 2017 classification) diagnosed between January 1999 December 2016 least 1-year follow-up. Treatment was defined as failure respond two or more appropriate ASMs. Exclusion criteria included eyelid myoclonia absence, myoclonic generalized tonic-clonic (GTC) seizure before developing absences. Results: The study population comprised 164 (65 males) 6.25-year-old on average onset. 22% had treatment-resistant seizures. first ASM Ethosuximide 63.4%, Valproic acid 23.2%, Lamotrigine 6.7%. Statistical differences response groups second type specifically GTC, the third ASM, EEG normalization. At last follow-up, 43.3% children seizure-free off 32.9% learning disabilities, 28% ADHD, 12.8 % anxiety. Conclusions: Photoparoxysmal not resistance. Neuropsychiatric common disabilities increased refractory